Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration

Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration

Summary: The hostile microenvironment of the retina in patients with age-related macular degeneration (AMD) may trigger epithelial-to-mesenchymal transition (EMT) of grafted retinal pigment epithelial (RPE) cells, thus attenuating the therapeutic outcome. Here, we transformed human dedifferentiated...

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Bibliographic Details
Main Authors: Haibin Tian, Zhiyang Chen, Xiaoman Zhu, Qingjian Ou, Zhe Wang, Binxin Wu, Jing-Ying Xu, Caixia Jin, Furong Gao, Juan Wang, Jingfa Zhang, Jieping Zhang, Lixia Lu, Guo-Tong Xu
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:iScience
Subjects:
Biological sciences
Molecular biology
Stem cells research
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222013220

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http://www.sciencedirect.com/science/article/pii/S2589004222013220

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