Paeonol Ameliorates Diabetic Renal Fibrosis Through Promoting the Activation of the Nrf2/ARE Pathway via Up-Regulating Sirt1

Paeonol Ameliorates Diabetic Renal Fibrosis Through Promoting the Activation of the Nrf2/ARE Pathway via Up-Regulating Sirt1

Diabetic nephropathy (DN) is rapidly becoming the leading cause of end-stage renal disease worldwide and a major cause of morbidity and mortality in patients of diabetes. The main pathological change of DN is renal fibrosis. Paeonol (PA), a single phenolic compound extracted from the root bark of Co...

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Bibliographic Details
Main Authors: Lei Zhang, Zhiquan Chen, Wenyan Gong, Yezi Zou, Futian Xu, Lihao Chen, Heqing Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
paeonol
oxidative stress
diabetic nephropathy
Sirt1
Nrf2/ARE pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00512/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.00512/full

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