CD56 regulates human NK cell cytotoxicity through Pyk2

CD56 regulates human NK cell cytotoxicity through Pyk2

Human natural killer (NK) cells are defined as CD56+CD3−. Despite its ubiquitous expression on human NK cells the role of CD56 (NCAM) in human NK cell cytotoxic function has not been defined. In non-immune cells, NCAM can induce signaling, mediate adhesion, and promote exocytosis through interaction...

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Bibliographic Details
Main Authors: Justin T Gunesch, Amera L Dixon, Tasneem AM Ebrahim, Melissa M Berrien-Elliott, Swetha Tatineni, Tejas Kumar, Everardo Hegewisch-Solloa, Todd A Fehniger, Emily M Mace
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-06-01
Series:eLife
Subjects:
natural killer cells
cytotoxicity
innate immunity
NCAM
Online Access:https://elifesciences.org/articles/57346

Internet

https://elifesciences.org/articles/57346

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