Variants of a putative baseplate wedge protein extend the host range of Pseudomonas phage K8

Variants of a putative baseplate wedge protein extend the host range of Pseudomonas phage K8

Abstract Background Narrow host range is a major limitation for phage applications, but phages can evolve expanded host range through adaptations in the receptor-binding proteins. Results Here, we report that Pseudomonas phage K8 can evolve broader host range and higher killing efficiency at the cos...

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Bibliographic Details
Main Authors: Li Sun, Jiajia You, Donghang Li, Zhiqiang Zhang, Xuying Qin, Wenjing Pang, Peize Li, Qingzhu Han, Yueying Li, Zhiwei Huang, Xixi Zhang, Mengxin Gong, Hongjiang Yang
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Microbiome
Subjects:
Phage mutants
Protein variants
Wedge protein
Viral gene reservoir
Online Access:https://doi.org/10.1186/s40168-022-01459-w

Internet

https://doi.org/10.1186/s40168-022-01459-w

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