Ex vivo expanded autologous polyclonal regulatory T cells suppress inhibitor formation in hemophilia

Ex vivo expanded autologous polyclonal regulatory T cells suppress inhibitor formation in hemophilia

Adoptive cell therapy utilizing ex vivo expanded polyclonal CD4+CD25+FOXP3+ regulatory T cells (Treg) is in use in clinical trials for the treatment of type 1 diabetes and prevention of graft versus host disease in bone marrow transplantation. Here, we seek to evaluate this approach in the treatment...

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Bibliographic Details
Main Authors: Debalina Sarkar, Moanaro Biswas, Gongxian Liao, Howard R Seay, George Q Perrin, David M Markusic, Brad E Hoffman, Todd M Brusko, Cox Terhorst, Roland W Herzog
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050116300973

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http://www.sciencedirect.com/science/article/pii/S2329050116300973

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