Molecular characterization of breast cancer cell pools with normal or reduced ability to respond to progesterone: a study based on RNA-seq

Molecular characterization of breast cancer cell pools with normal or reduced ability to respond to progesterone: a study based on RNA-seq

Abstract Background About one-third of patients with estrogen receptor alpha (ERα)-positive breast cancer have tumors which are progesterone receptor (PR) negative. PR is an important prognostic factor in breast cancer. Patients with ERα-positive/PR-negative tumors have shorter disease-free and over...

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Bibliographic Details
Main Authors: Mariana Bustamante Eduardo, Irene Keller, Nathalie Schuster, Stefan Aebi, Rolf Jaggi
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Journal of Genetic Engineering and Biotechnology
Subjects:
Breast cancer
Estrogen receptor alpha
Progesterone receptor
Gene expression
RNA sequencing
CRISPR/Cas9
Online Access:https://doi.org/10.1186/s43141-023-00541-6

Internet

https://doi.org/10.1186/s43141-023-00541-6

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