Personalised azithromycin+metronidazole (PAZAZ), in combination with standard induction therapy, to achieve a faecal microbiome community structure and metagenome changes associated with sustained remission in paediatric Crohn’s disease (CD): protocol of a pilot study

Personalised azithromycin+metronidazole (PAZAZ), in combination with standard induction therapy, to achieve a faecal microbiome community structure and metagenome changes associated with sustained remission in paediatric Crohn’s disease (CD): protocol of a pilot study

Introduction Early relapse in Crohn’s disease (CD) is associated with a more severe disease course. The microbiome plays a crucial role, yet strategies targeting the microbiome are underrepresented in current guidelines. We hypothesise that early manipulation of the microbiome will improve clinical...

Full description

Bibliographic Details
Main Authors: Marc A Benninga, Melvin B Heyman, Anthony Otley, Tim de Meij, Wouter J de Jonge, Charlotte M Verburgt, Katherine A Dunn, Sofia Verstraete, Withney Sunseri, Francisco Sylvester, Andre Comeau, Morgan Langille, Johan E Van Limbergen
Format: Article
Language:English
Published: BMJ Publishing Group 2023-02-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/13/2/e064944.full

Internet

https://bmjopen.bmj.com/content/13/2/e064944.full

Similar Items