The integrated stress response remodels the microtubule-organizing center to clear unfolded proteins following proteotoxic stress

The integrated stress response remodels the microtubule-organizing center to clear unfolded proteins following proteotoxic stress

Cells encountering stressful situations activate the integrated stress response (ISR) pathway to limit protein synthesis and redirect translation to better cope. The ISR has also been implicated in cancers, but redundancies in the stress-sensing kinases that trigger the ISR have posed hurdles to dis...

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Bibliographic Details
Main Authors: Brian Hurwitz, Nicola Guzzi, Anita Gola, Vincent F Fiore, Ataman Sendoel, Maria Nikolova, Douglas Barrows, Thomas S Carroll, H Amalia Pasolli, Elaine Fuchs
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-06-01
Series:eLife
Subjects:
squamous cell carcinoma
integrated stress response
translational control
cytoskeleton
cell biology
stem cell
Online Access:https://elifesciences.org/articles/77780

Internet

https://elifesciences.org/articles/77780

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