DNA fragility at the KMT2A/MLL locus: insights from old and new technologies
The Mixed-Lineage Leukaemia (MLL/KMT2A) gene is frequently rearranged in childhood and adult acute leukaemia (AL) and in secondary leukaemias occurring after therapy with DNA topoisomerase targeting anti-cancer agents such as etoposide (t-AL). MLL/KMT2A chromosome translocation break sites in AL pat...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
The Royal Society
2023-01-01
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| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsob.220232 |