Enhanced Efficacy of a Codon-Optimized DNA Vaccine Encoding the Glycoprotein Precursor Gene of Lassa Virus in a Guinea Pig Disease Model When Delivered by Dermal Electroporation

Enhanced Efficacy of a Codon-Optimized DNA Vaccine Encoding the Glycoprotein Precursor Gene of Lassa Virus in a Guinea Pig Disease Model When Delivered by Dermal Electroporation

Lassa virus (LASV) causes a severe, often fatal, hemorrhagic fever endemic to West Africa. Presently, there are no FDA-licensed medical countermeasures for this disease. In a pilot study, we constructed a DNA vaccine (pLASV-GPC) that expressed the LASV glycoprotein precursor gene (GPC). This plasmid...

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Bibliographic Details
Main Authors: Niranjan Y. Sardesai, Connie S. Schmaljohn, Catherine V. Badger, Mary C. Guttieri, Kristin W. Spik, Carl I. Shaia, Amy C. Shurtleff, Todd M. Bell, Kate E. Broderick, Eric R. Wilkinson, Kathleen A. Cashman
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:Vaccines
Subjects:
Lassa fever
Lassa virus
arenavirus
guinea pigs
dermal electroporation
vaccination
vaccine
Online Access:http://www.mdpi.com/2076-393X/1/3/262

Internet

http://www.mdpi.com/2076-393X/1/3/262

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