Gain-of-Function Properties of a Dynamin 2 Mutant Implicated in Charcot-Marie-Tooth Disease

Gain-of-Function Properties of a Dynamin 2 Mutant Implicated in Charcot-Marie-Tooth Disease

Mutations in the gene encoding dynamin 2 (DNM2), a GTPase that catalyzes membrane constriction and fission, are associated with two autosomal-dominant motor disorders, Charcot-Marie-Tooth disease (CMT) and centronuclear myopathy (CNM), which affect nerve and muscle, respectively. Many of these mutat...

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Bibliographic Details
Main Authors: Tara C. Tassin, Barbara Barylko, Per Niklas Hedde, Yan Chen, Derk D. Binns, Nicholas G. James, Joachim D. Mueller, David M. Jameson, Ronald Taussig, Joseph P. Albanesi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
dynamin
Charcot-Marie-Tooth disease
centronuclear myopathy
tyrosine phosphorylation
FLIM/FRET
fluorescence fluctuation spectroscopy
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.745940/full

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https://www.frontiersin.org/articles/10.3389/fncel.2021.745940/full

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