Dendritic cell-mediated cross presentation of tumor-derived peptides is biased against plasma membrane proteins

Dendritic cell-mediated cross presentation of tumor-derived peptides is biased against plasma membrane proteins

Background For effective tumor elimination, cytotoxic CD8+ T cells must recognize tumor-derived antigens presented on class I major histocompatibility complex (MHC-I). Despite a general association between the expression of immunogenic antigens, typically neoantigens, and response to immunotherapy,...

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Bibliographic Details
Main Authors: Stefani Spranger, Fiona Chatterjee, Esmee P Hoefsmit, Tim B Fessenden, Lauren E Stopfer, Julian Zulueta, Josh Mesfin, Therese Cordero Dumit, Irene Reijers, Christian Blank, Forest White
Format: Article
Language:English
Published: BMJ Publishing Group 2022-07-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/10/7/e004159.full

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https://jitc.bmj.com/content/10/7/e004159.full

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