Stochastic Inheritance of Division and Death Times Determines the Size and Phenotype of CD8+ T Cell Families

After antigen stimulation cognate naïve CD8+ T cells undergo rapid proliferation and ultimately their progeny differentiates into short-lived effectors and longer-lived memory T cells. Although the expansion of individual cells is very heterogeneous, the kinetics are reproducible at the level of the...

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Bibliographic Details
Main Authors: Aridaman Pandit, Rob J. De Boer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00436/full