Synergistic effect of endurance training and nettle leaf extract on the IDO1-KYN-AHR pathway homeostasis and inhibiting of liver toxicity in rats with STZ-induced diabetes

Synergistic effect of endurance training and nettle leaf extract on the IDO1-KYN-AHR pathway homeostasis and inhibiting of liver toxicity in rats with STZ-induced diabetes

IntroductionDiabetes adversely affects a number of hepatic molecular pathways, including the kynurenine (KYN) pathway. KYN is produced by indoleamine 2,3-dioxygenase (IDO) and activates the aryl hydrocarbon receptor (AHR). This study evaluated the effect of endurance training (EndTr) and nettle leaf...

Full description

Bibliographic Details
Main Authors: Rouhollah Haghshenas, Younes Aftabi, Saied Doaei, Maryam Gholamalizadeh
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Endocrinology
Subjects:
AHR pathway
kynurenine
IDO1
diabetes
exercise
Urtica dioica L
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1071424/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1071424/full

Similar Items