Itavastatin and resveratrol increase triosephosphate isomerase protein in a newly identified variant of TPI deficiency

Itavastatin and resveratrol increase triosephosphate isomerase protein in a newly identified variant of TPI deficiency

Triosephosphate isomerase (TPI) deficiency (TPI Df) is an untreatable glycolytic enzymopathy that results in hemolytic anemia, progressive muscular impairment and irreversible brain damage. Although there is a ‘common’ mutation (TPIE105D), other pathogenic mutations have been described. We identifie...

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Bibliographic Details
Main Authors: Andrew P. VanDemark, Stacy L. Hrizo, Samantha L. Eicher, Jules Kowalski, Tracey D. Myers, Megan R. Pfeifer, Kacie N. Riley, Dwight D. Koeberl, Michael J. Palladino
Format: Article
Language:English
Published: The Company of Biologists 2022-05-01
Series:Disease Models & Mechanisms
Subjects:
biochemistry
glycolytic dysfunction
structural biology
triosephosphate isomerase
Online Access:http://dmm.biologists.org/content/15/5/dmm049261

Internet

http://dmm.biologists.org/content/15/5/dmm049261

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