Strain-Dependent Modifier Genes Determine Survival in Zfp423 Mice

Strain-Dependent Modifier Genes Determine Survival in Zfp423 Mice

Zfp423 encodes a transcriptional regulatory protein that interacts with canonical signaling and lineage pathways. Mutations in mouse Zfp423 or its human ortholog ZNF423 are associated with a range of developmental abnormalities reminiscent of ciliopathies, including cerebellar vermis hypoplasia and...

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Détails bibliographiques
Auteurs principaux: Wendy A. Alcaraz, Zheng Liu, Phoebe Valdes, Edward Chen, Alan G. Valdovino Gonzalez, Shelby Wade, Cinny Wong, Eunnie Kim, Hsiang-Hua M. Chen, Alison Ponn, Dorothy Concepcion, Bruce A. Hamilton
Format: Article
Langue:English
Publié: Oxford University Press 2020-11-01
Collection:G3: Genes, Genomes, Genetics
Sujets:
brain development
ciliopathy
smad signaling
inbred strains
Accès en ligne:http://g3journal.org/lookup/doi/10.1534/g3.120.401720

Internet

http://g3journal.org/lookup/doi/10.1534/g3.120.401720

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