Characterization of the Metabolic Response of <i>Streptomyces clavuligerus</i> to Shear Stress in Stirred Tanks and Single-Use 2D Rocking Motion Bioreactors for Clavulanic Acid Production

Characterization of the Metabolic Response of <i>Streptomyces clavuligerus</i> to Shear Stress in Stirred Tanks and Single-Use 2D Rocking Motion Bioreactors for Clavulanic Acid Production

<i>Streptomyces clavuligerus</i> is a gram-positive filamentous bacterium notable for producing clavulanic acid (CA), an inhibitor of &#946;-lactamase enzymes, which confers resistance to bacteria against several antibiotics. Here we present a comparative analysis of the morphologica...

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Bibliographic Details
Main Authors: David Gómez-Ríos, Stefan Junne, Peter Neubauer, Silvia Ochoa, Rigoberto Ríos-Estepa, Howard Ramírez-Malule
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Antibiotics
Subjects:
clavulanic acid
antibiotic
<i>streptomyces</i>
bioreactors
shear stress
oxygen transfer
single-use
stirred tank
morphology
fed-batch
Online Access:https://www.mdpi.com/2079-6382/8/4/168

Internet

https://www.mdpi.com/2079-6382/8/4/168

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