Theranostic Uses of the Heme Pathway in Neuro-Oncology: Protoporphyrin IX (PpIX) and Its Journey from Photodynamic Therapy (PDT) through Photodynamic Diagnosis (PDD) to Sonodynamic Therapy (SDT)

Theranostic Uses of the Heme Pathway in Neuro-Oncology: Protoporphyrin IX (PpIX) and Its Journey from Photodynamic Therapy (PDT) through Photodynamic Diagnosis (PDD) to Sonodynamic Therapy (SDT)

ALA PDT, first approved as a topical therapy to treat precancerous skin lesions in 1999, targets the heme pathway selectively in cancers. When provided with excess ALA, the fluorescent photosensitizer PpIX accumulates primarily in cancer tissue, and ALA PDD is used to identify bladder and brain canc...

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Bibliographic Details
Main Authors: Stuart L. Marcus, Mark P. de Souza
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cancers
Subjects:
aminolevulinic acid
5-ALA
photodynamic therapy
sonodynamic therapy
photodynamic diagnosis
focused ultrasound
Online Access:https://www.mdpi.com/2072-6694/16/4/740

Internet

https://www.mdpi.com/2072-6694/16/4/740

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