A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene

A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene

A novel, low-cost method for the preparation of not easily accessible free 3-aminoindoles has been developed. This approach is based on a well-established reaction between indoles and nitrostyrene in the presence of phosphorous acid, which results in the formation of 4′-phenyl-4′H-spiro[indole-3,5′-...

Full description

Bibliographic Details
Main Authors: Nicolai A. Aksenov, Nikolai A. Arutiunov, Igor A. Kurenkov, Vladimir V. Malyuga, Dmitrii A. Aksenov, Daria S. Momotova, Anna M. Zatsepilina, Elizaveta A. Chukanova, Alexander V. Leontiev, Alexander V. Aksenov
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Molecules
Subjects:
C3-amination of indoles
cascade transformations
phenylacetonitrile extrusion
Online Access:https://www.mdpi.com/1420-3049/28/9/3657

Internet

https://www.mdpi.com/1420-3049/28/9/3657

Similar Items