A Nurr1 point mutant, implicated in Parkinson’s disease, uncouples ERK1/2-dependent regulation of tyrosine hydroxylase transcription

A Nurr1 point mutant, implicated in Parkinson’s disease, uncouples ERK1/2-dependent regulation of tyrosine hydroxylase transcription

The orphan nuclear receptor NURR1 is critical for the development of mesencephalic dopamine neurons and directly regulates tyrosine hydroxylase (TH) via specific NGFI-B response elements (NBRE). We identified a Parkinson’s disease patient with a NURR1 mutation, resulting in a p.Ser125Cys change, imm...

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Bibliographic Details
Main Authors: Kirsten X. Jacobsen, Heather MacDonald, Sylvie Lemonde, Mireille Daigle, David A. Grimes, Dennis E. Bulman, Paul R. Albert
Format: Article
Language:English
Published: Elsevier 2008-01-01
Series:Neurobiology of Disease
Subjects:
Dopamine
Development
Transcription
Orphan nuclear receptor
Point Mutation
Phosphorylation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107001908

Internet

http://www.sciencedirect.com/science/article/pii/S0969996107001908

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