Targeting extracellular Hsp90: A unique frontier against cancer

The molecular chaperone Heat Shock Protein-90 (Hsp90) is known to interact with over 300 client proteins as well as regulatory factors (eg. nucleotide and proteins) that facilitate execution of its role as a chaperone and, ultimately, client protein activation. Hsp90 associates transiently with thes...

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Bibliographic Details
Main Authors: Rebecca A. Sager, Farzana Khan, Lorenzo Toneatto, SarahBeth D. Votra, Sarah J. Backe, Mark R. Woodford, Mehdi Mollapour, Dimitra Bourboulia
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.982593/full