Robust Immune Response and Protection against Lethal Pneumococcal Challenge with a Recombinant BCG-PspA-PdT Prime/Boost Scheme Administered to Neonatal Mice

Robust Immune Response and Protection against Lethal Pneumococcal Challenge with a Recombinant BCG-PspA-PdT Prime/Boost Scheme Administered to Neonatal Mice

Pneumococcal diseases are an important public health problem, with high mortality rates in young children. Although conjugated pneumococcal vaccines offer high protection against invasive pneumococcal diseases, this is restricted to vaccine serotypes, leading to serotype replacement. Furthermore, th...

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Bibliographic Details
Main Authors: Monalisa Martins Trentini, Dunia Rodriguez, Alex Issamu Kanno, Cibelly Goulart, Michelle Darrieux, Luciana Cezar de Cerqueira Leite
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Vaccines
Subjects:
recombinant BCG
neonatal mice
streptococcus pneumoniae
prime/boost strategy
Online Access:https://www.mdpi.com/2076-393X/12/2/122

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https://www.mdpi.com/2076-393X/12/2/122

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