Discovery of DNA aptamers targeting SARS-CoV-2 nucleocapsid protein and protein-binding epitopes for label-free COVID-19 diagnostics

Discovery of DNA aptamers targeting SARS-CoV-2 nucleocapsid protein and protein-binding epitopes for label-free COVID-19 diagnostics

The spread of COVID-19 has affected billions of people across the globe, and the diagnosis of viral infection still needs improvement. Because of high immunogenicity and abundant expression during viral infection, SARS-CoV-2 nucleocapsid (N) protein could be an important diagnostic marker. This stud...

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Bibliographic Details
Main Authors: Suttinee Poolsup, Emil Zaripov, Nico Hüttmann, Zoran Minic, Polina V. Artyushenko, Irina A. Shchugoreva, Felix N. Tomilin, Anna S. Kichkailo, Maxim V. Berezovski
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Diagnostics and Biosensors
COVID-19 diagnosis
SARS-CoV-2 nucleocapsid detection
label-free optical aptasensor
aptamer selection
biolayer interferometry
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123000306

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http://www.sciencedirect.com/science/article/pii/S2162253123000306

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