Characterizing the Contributions of Various Clostridium perfringens Enterotoxin Properties to In Vivo and In Vitro Permeability Effects

Characterizing the Contributions of Various Clostridium perfringens Enterotoxin Properties to In Vivo and In Vitro Permeability Effects

ABSTRACT Clostridium perfringens enterotoxin (CPE) is thought to cause lethal enterotoxemia when absorbed from the intestinal lumen into the circulation. CPE action sequentially involves receptor-binding, oligomerization into a prepore, and pore formation. To explore the mechanistic basis by which C...

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Bibliographic Details
Main Authors: Archana Shrestha, Mauricio A. Navarro, Juliann Beingesser, Anibal G. Armien, Francisco A. Uzal, Bruce A. McClane
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:mSphere
Subjects:
Clostridium perfringens
enterotoxin
enterotoxemia
permeability alterations
pore formation
Caco-2 cells
Online Access:https://journals.asm.org/doi/10.1128/msphere.00276-22

Internet

https://journals.asm.org/doi/10.1128/msphere.00276-22

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