Association between genetic variants in TREM1, CXCL10, IL4, CXCL8 and TLR7 genes with the occurrence of congenital Zika syndrome and severe microcephaly
Abstract Congenital Zika syndrome (CZS) is a cluster of malformations induced by Zika virus (ZIKV) infection and the underline mechanisms involved in its occurrence are yet not fully understood. Along with epidemiological and environmental factors, the genetic host factors are suggested as important...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-30342-3 |
| _version_ | 1797864988252045312 |
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| author | Camilla Natália Oliveira Santos Lucas Sousa Magalhães Adriana Barbosa de Lima Fonseca Ana Jovina Barreto Bispo Roseane Lima Santos Porto Juliana Cardoso Alves Cliomar Alves dos Santos Jaira Vanessa de Carvalho Angela Maria da Silva Mauro Martins Teixeira Roque Pacheco de Almeida Priscila Lima dos Santos Amélia Ribeiro de Jesus |
| author_facet | Camilla Natália Oliveira Santos Lucas Sousa Magalhães Adriana Barbosa de Lima Fonseca Ana Jovina Barreto Bispo Roseane Lima Santos Porto Juliana Cardoso Alves Cliomar Alves dos Santos Jaira Vanessa de Carvalho Angela Maria da Silva Mauro Martins Teixeira Roque Pacheco de Almeida Priscila Lima dos Santos Amélia Ribeiro de Jesus |
| author_sort | Camilla Natália Oliveira Santos |
| collection | DOAJ |
| description | Abstract Congenital Zika syndrome (CZS) is a cluster of malformations induced by Zika virus (ZIKV) infection and the underline mechanisms involved in its occurrence are yet not fully understood. Along with epidemiological and environmental factors, the genetic host factors are suggested as important to the CZS occurrence and development, however, few studies have evaluated this. This study enrolled a total of 245 individuals in a case–control association study compound a cohort of high specific interest constituted by 75 mothers who had delivered CZS infants, their 76 infants, and 47 mothers that had delivered healthy infants, and their 47 infants. Sixteen single-nucleotide polymorphisms on TREM1, CXCL10, IL4, CXCL8, TLR3, TLR7, IFNR1, CXCR1, IL10, CCR2 and CCR5 genes were genotyped to investigate their association as risk factors to CZS. The results show an association between C allele at TREM1 rs2234246 and C allele at IL4 rs224325 in mothers infected with ZIKV during pregnancy, with the increased susceptibility to CZS occurrence in their infants and the SNP CXCL8 rs4073 and the G allele at CXCL10 rs4508917 with presence of CZS microcephaly in the infants. Furthermore, the T allele at CXCL8 rs4073 and TRL7 rs179008 SNPs were associated with the severity of microcephaly in children with CZS. These results suggest that these polymorphisms in genes of innate immune responses addressed here are associated to increased risk of occurrence and severity of CZS in pregnant mothers infected with ZIKV and their CZS infants. |
| first_indexed | 2024-04-09T23:00:45Z |
| format | Article |
| id | doaj.art-6e6fc852bd8e4a28ae54f2179ac2d64a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T23:00:45Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6e6fc852bd8e4a28ae54f2179ac2d64a2023-03-22T10:59:18ZengNature PortfolioScientific Reports2045-23222023-03-0113111010.1038/s41598-023-30342-3Association between genetic variants in TREM1, CXCL10, IL4, CXCL8 and TLR7 genes with the occurrence of congenital Zika syndrome and severe microcephalyCamilla Natália Oliveira Santos0Lucas Sousa Magalhães1Adriana Barbosa de Lima Fonseca2Ana Jovina Barreto Bispo3Roseane Lima Santos Porto4Juliana Cardoso Alves5Cliomar Alves dos Santos6Jaira Vanessa de Carvalho7Angela Maria da Silva8Mauro Martins Teixeira9Roque Pacheco de Almeida10Priscila Lima dos Santos11Amélia Ribeiro de Jesus12Immunology and Molecular Biology Laboratory and Graduate Program in Health Sciences, University Hospital of Federal University of SergipeImmunology and Molecular Biology Laboratory and Graduate Program in Health Sciences, University Hospital of Federal University of SergipePediatric Division of University Hospital of the Federal University of SergipePediatric Division of University Hospital of the Federal University of SergipePediatric Division of University Hospital of the Federal University of SergipeImmunology and Molecular Biology Laboratory and Graduate Program in Health Sciences, University Hospital of Federal University of SergipeCentral Public Health Laboratory of Sergipe, Health Foundation Parreiras HortaDepartment of Medicine of University Hospital, Federal University of SergipeImmunology and Molecular Biology Laboratory and Graduate Program in Health Sciences, University Hospital of Federal University of SergipeFederal University of Minas GeraisImmunology and Molecular Biology Laboratory and Graduate Program in Health Sciences, University Hospital of Federal University of SergipeImmunology and Molecular Biology Laboratory and Graduate Program in Health Sciences, University Hospital of Federal University of SergipeImmunology and Molecular Biology Laboratory and Graduate Program in Health Sciences, University Hospital of Federal University of SergipeAbstract Congenital Zika syndrome (CZS) is a cluster of malformations induced by Zika virus (ZIKV) infection and the underline mechanisms involved in its occurrence are yet not fully understood. Along with epidemiological and environmental factors, the genetic host factors are suggested as important to the CZS occurrence and development, however, few studies have evaluated this. This study enrolled a total of 245 individuals in a case–control association study compound a cohort of high specific interest constituted by 75 mothers who had delivered CZS infants, their 76 infants, and 47 mothers that had delivered healthy infants, and their 47 infants. Sixteen single-nucleotide polymorphisms on TREM1, CXCL10, IL4, CXCL8, TLR3, TLR7, IFNR1, CXCR1, IL10, CCR2 and CCR5 genes were genotyped to investigate their association as risk factors to CZS. The results show an association between C allele at TREM1 rs2234246 and C allele at IL4 rs224325 in mothers infected with ZIKV during pregnancy, with the increased susceptibility to CZS occurrence in their infants and the SNP CXCL8 rs4073 and the G allele at CXCL10 rs4508917 with presence of CZS microcephaly in the infants. Furthermore, the T allele at CXCL8 rs4073 and TRL7 rs179008 SNPs were associated with the severity of microcephaly in children with CZS. These results suggest that these polymorphisms in genes of innate immune responses addressed here are associated to increased risk of occurrence and severity of CZS in pregnant mothers infected with ZIKV and their CZS infants.https://doi.org/10.1038/s41598-023-30342-3 |
| spellingShingle | Camilla Natália Oliveira Santos Lucas Sousa Magalhães Adriana Barbosa de Lima Fonseca Ana Jovina Barreto Bispo Roseane Lima Santos Porto Juliana Cardoso Alves Cliomar Alves dos Santos Jaira Vanessa de Carvalho Angela Maria da Silva Mauro Martins Teixeira Roque Pacheco de Almeida Priscila Lima dos Santos Amélia Ribeiro de Jesus Association between genetic variants in TREM1, CXCL10, IL4, CXCL8 and TLR7 genes with the occurrence of congenital Zika syndrome and severe microcephaly Scientific Reports |
| title | Association between genetic variants in TREM1, CXCL10, IL4, CXCL8 and TLR7 genes with the occurrence of congenital Zika syndrome and severe microcephaly |
| title_full | Association between genetic variants in TREM1, CXCL10, IL4, CXCL8 and TLR7 genes with the occurrence of congenital Zika syndrome and severe microcephaly |
| title_fullStr | Association between genetic variants in TREM1, CXCL10, IL4, CXCL8 and TLR7 genes with the occurrence of congenital Zika syndrome and severe microcephaly |
| title_full_unstemmed | Association between genetic variants in TREM1, CXCL10, IL4, CXCL8 and TLR7 genes with the occurrence of congenital Zika syndrome and severe microcephaly |
| title_short | Association between genetic variants in TREM1, CXCL10, IL4, CXCL8 and TLR7 genes with the occurrence of congenital Zika syndrome and severe microcephaly |
| title_sort | association between genetic variants in trem1 cxcl10 il4 cxcl8 and tlr7 genes with the occurrence of congenital zika syndrome and severe microcephaly |
| url | https://doi.org/10.1038/s41598-023-30342-3 |
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