Epigenetic reprogramming-induced guanidinoacetic acid synthesis promotes pancreatic cancer metastasis and transcription-activating histone modifications

Epigenetic reprogramming-induced guanidinoacetic acid synthesis promotes pancreatic cancer metastasis and transcription-activating histone modifications

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) tends to undergo distant metastasis, especially liver metastasis, leading to a poor prognosis. Metabolic remodelling and epigenetic reprogramming are two important hallmarks of malignant tumours and participate in regulating PDAC tumorigene...

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Bibliographic Details
Main Authors: Jinshou Yang, Bo Ren, Jie Ren, Gang Yang, Yuan Fang, Xing Wang, Feihan Zhou, Lei You, Yupei Zhao
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Metabolomics
Epigenetics
H3K4me3
c-Myc
Metastasis
Online Access:https://doi.org/10.1186/s13046-023-02698-x

Internet

https://doi.org/10.1186/s13046-023-02698-x

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