Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium

Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium

T-cell development in the thymus is dependent on Notch signaling induced by the interaction of Notch1, present on immigrant cells, with a Notch ligand, delta-like (Dll) 4, on the thymic epithelial cells. Phylogenetic analysis characterizing the properties of the Dll4 molecule suggests that Dll4 emer...

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Bibliographic Details
Main Authors: Ken-ichi Hirano, Hiroyuki Hosokawa, Takashi Yahata, Kiyoshi Ando, Masayuki Tanaka, Jin Imai, Masaki Yazawa, Masato Ohtsuka, Naoko Negishi, Sonoko Habu, Takehito Sato, Katsuto Hozumi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
delta-like 1
delta-like 4
Notch1
Notch2
thymus
phylogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.852427/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.852427/full

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