Granzyme B is dispensable in the development of diabetes in non-obese diabetic mice.

Granzyme B is dispensable in the development of diabetes in non-obese diabetic mice.

Pancreatic beta cell destruction in type 1 diabetes is mediated by cytotoxic CD8(+) T lymphoctyes (CTL). Granzyme B is an effector molecule used by CTL to kill target cells. We previously showed that granzyme B-deficient allogeneic CTL inefficiently killed pancreatic islets in vitro. We generated gr...

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Bibliographic Details
Main Authors: Zia U Mollah, Kate L Graham, Balasubramanian Krishnamurthy, Prerak Trivedi, Thomas C Brodnicki, Joseph A Trapani, Thomas W Kay, Helen E Thomas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3392222?pdf=render

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http://europepmc.org/articles/PMC3392222?pdf=render

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