Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions

Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions

The human ortholog MRGPRX2 and the mice ortholog, Mrgprb2 are activated by basic secretagogues and neurokinins. A number of commonly used small-molecule drugs (e.g., neuromuscular blocking agents, fluoroquinolones, vancomycin) have been recently shown to activate these receptors under in vitro exper...

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Bibliographic Details
Main Authors: Grzegorz Porebski, Kamila Kwiecien, Magdalena Pawica, Mateusz Kwitniewski
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
anaphylaxis
drug allergy
drug hypersensitivity
mast cells
MRGPRX2
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03027/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03027/full

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