Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions
The human ortholog MRGPRX2 and the mice ortholog, Mrgprb2 are activated by basic secretagogues and neurokinins. A number of commonly used small-molecule drugs (e.g., neuromuscular blocking agents, fluoroquinolones, vancomycin) have been recently shown to activate these receptors under in vitro exper...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.03027/full |
| _version_ | 1818162706649186304 |
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| author | Grzegorz Porebski Kamila Kwiecien Magdalena Pawica Mateusz Kwitniewski |
| author_facet | Grzegorz Porebski Kamila Kwiecien Magdalena Pawica Mateusz Kwitniewski |
| author_sort | Grzegorz Porebski |
| collection | DOAJ |
| description | The human ortholog MRGPRX2 and the mice ortholog, Mrgprb2 are activated by basic secretagogues and neurokinins. A number of commonly used small-molecule drugs (e.g., neuromuscular blocking agents, fluoroquinolones, vancomycin) have been recently shown to activate these receptors under in vitro experimental conditions, what results in mast cell degranulation. The above drugs are also known to cause IgE-mediated anaphylactic reactions in allergic patients. The new findings on mechanisms of drug-induced mast cell degranulation may modify the current management of drug hypersensitivity reactions. Clinical interpretation of mild drug-provoked hypersensitivity reactions, interpretation of skin test with a drug of interest or further recommendations for patients suspected of drug allergy are likely to be reconsidered. In the paper we discussed future directions in research on identification and differentiation of MRGPRX2-mediated and IgE-dependent mast cell degranulation in patients presenting clinical features of drug-induced hypersensitivity reactions. |
| first_indexed | 2024-12-11T16:37:56Z |
| format | Article |
| id | doaj.art-6e7b0c0d0dbc434593d3f4e72e1cc07f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T16:37:56Z |
| publishDate | 2018-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6e7b0c0d0dbc434593d3f4e72e1cc07f2022-12-22T00:58:24ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-12-01910.3389/fimmu.2018.03027412299Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity ReactionsGrzegorz Porebski0Kamila Kwiecien1Magdalena Pawica2Mateusz Kwitniewski3Department of Clinical and Environmental Allergology, Jagiellonian University Medical College, Krakow, PolandDepartment of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, PolandDepartment of Clinical and Environmental Allergology, Jagiellonian University Medical College, Krakow, PolandDepartment of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, PolandThe human ortholog MRGPRX2 and the mice ortholog, Mrgprb2 are activated by basic secretagogues and neurokinins. A number of commonly used small-molecule drugs (e.g., neuromuscular blocking agents, fluoroquinolones, vancomycin) have been recently shown to activate these receptors under in vitro experimental conditions, what results in mast cell degranulation. The above drugs are also known to cause IgE-mediated anaphylactic reactions in allergic patients. The new findings on mechanisms of drug-induced mast cell degranulation may modify the current management of drug hypersensitivity reactions. Clinical interpretation of mild drug-provoked hypersensitivity reactions, interpretation of skin test with a drug of interest or further recommendations for patients suspected of drug allergy are likely to be reconsidered. In the paper we discussed future directions in research on identification and differentiation of MRGPRX2-mediated and IgE-dependent mast cell degranulation in patients presenting clinical features of drug-induced hypersensitivity reactions.https://www.frontiersin.org/article/10.3389/fimmu.2018.03027/fullanaphylaxisdrug allergydrug hypersensitivitymast cellsMRGPRX2 |
| spellingShingle | Grzegorz Porebski Kamila Kwiecien Magdalena Pawica Mateusz Kwitniewski Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions Frontiers in Immunology anaphylaxis drug allergy drug hypersensitivity mast cells MRGPRX2 |
| title | Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions |
| title_full | Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions |
| title_fullStr | Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions |
| title_full_unstemmed | Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions |
| title_short | Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions |
| title_sort | mas related g protein coupled receptor x2 mrgprx2 in drug hypersensitivity reactions |
| topic | anaphylaxis drug allergy drug hypersensitivity mast cells MRGPRX2 |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.03027/full |
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