Inhibition of HOXD11 promotes cartilage degradation and induces osteoarthritis development

Abstract The 5′-HOXD genes are important for chondrogenesis in vertebrates, but their roles in osteoarthritis (OA) are still ambiguous. In our study, 5′-HOXD genes involvement contributing to cartilage degradation and OA was investigated. In bioinformatics analysis of 5′-HOXD genes, we obtained the...

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Bibliographic Details
Main Authors: Quan Hong, Zhong-Xun Liu, Hai-Feng Liang, De-Guang Wu, Yan Chen, Bo Yu
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Online Access:https://doi.org/10.1186/s13018-024-04573-7