Anticancer Cytotoxic Activity of Bispidine Derivatives Associated with the Increasing Catabolism of Polyamines

Anticancer Cytotoxic Activity of Bispidine Derivatives Associated with the Increasing Catabolism of Polyamines

Polyamine (PA) catabolism is often reduced in cancer cells. The activation of this metabolic pathway produces cytotoxic substances that might cause apoptosis in cancer cells. Chemical compounds able to restore the level of PA catabolism in tumors could become potential antineoplastic agents. The sea...

Full description

Bibliographic Details
Main Authors: Ekaterina V. Neborak, Altynay B. Kaldybayeva, Lylia Bey, Aigul Y. Malmakova, Anna S. Tveritinova, Abdullah Hilal, Valentina K. Yu, Maria V. Ploskonos, Marina V. Komarova, Enzo Agostinelli, Dmitry D. Zhdanov
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
bispidines
polyamines
polyamine catabolism
cancer cell lines
antiproliferative activity
screening
Online Access:https://www.mdpi.com/1420-3049/27/12/3872

Internet

https://www.mdpi.com/1420-3049/27/12/3872

Similar Items