TERT Promoter Revertant Mutation Inhibits Melanoma Growth through Intrinsic Apoptosis

TERT Promoter Revertant Mutation Inhibits Melanoma Growth through Intrinsic Apoptosis

Human telomerase is a specialized DNA polymerase whose catalytic core includes both TERT and human telomerase RNA (hTR). Telomerase in humans, which is silent in most somatic cells, is activated to maintain the telomere length (TEL) in various types of cancer cells, including melanoma. In the vast m...

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Bibliographic Details
Main Authors: Yanbing Wang, Yiwu Chen, Chang Li, Zhiwei Xiao, Hongming Yuan, Yuanzhu Zhang, Daxin Pang, Xiaochun Tang, Mengjing Li, Hongsheng Ouyang
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Biology
Subjects:
TERT promoter
revertant mutation
melanoma
Bcl-2
intrinsic apoptosis
Online Access:https://www.mdpi.com/2079-7737/11/1/141

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https://www.mdpi.com/2079-7737/11/1/141

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