Cigarette smoke restricts the ability of mesenchymal cells to support lung epithelial organoid formation

Cigarette smoke restricts the ability of mesenchymal cells to support lung epithelial organoid formation

Adequate lung epithelial repair relies on supportive interactions within the epithelial niche, including interactions with WNT-responsive fibroblasts. In fibroblasts from patients with chronic obstructive pulmonary disease (COPD) or upon in vitro cigarette smoke exposure, Wnt/β-catenin signalling is...

Full description

Bibliographic Details
Main Authors: P. P. S. J. Khedoe, W. A. A. M. van Schadewijk, M. Schwiening, J. P. Ng-Blichtfeldt, S. J. Marciniak, J. Stolk, R. Gosens, P. S. Hiemstra
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cigarette smoke extract
lung epithelial organoid
COPD
fibroblasts
oxidative stress
ER stress
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1165581/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1165581/full

Similar Items