Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against <i>Fasciola hepatica</i>

Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against <i>Fasciola hepatica</i>

Infection with <i>Fasciola hepatica</i> (liver fluke) causes fasciolosis (or fascioliasis) and poses a considerable economic as well as welfare burden to both the agricultural and animal health sectors. Here, we explore the ex vivo anthelmintic potential of synthetic derivatives of heder...

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Bibliographic Details
Main Authors: Anand Chakroborty, Deiniol R. Pritchard, Marc E. Bouillon, Anna Cervi, Rolf Kraehenbuehl, Charlotte Wild, Caroline Fenn, Peter Holdsworth, Colin Capner, Gilda Padalino, Josephine E. Forde-Thomas, Joseph Payne, Brendan G. Smith, Maggie Fisher, Martina Lahmann, Mark S. Baird, Karl F. Hoffmann
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Pharmaceutics
Subjects:
<i>Fasciola hepatica</i>
anthelmintic drug discovery
<i>Hedera helix</i>
saponins and hederagenin
Online Access:https://www.mdpi.com/1999-4923/15/7/1869

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https://www.mdpi.com/1999-4923/15/7/1869

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