TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis

TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis

Abstract Background Tandem C2 domains, nuclear (TC2N) is a C2 domain-containing protein that belongs to the carboxyl-terminal type (C-type) tandem C2 protein family, and acts as an oncogenic driver in several cancers. Previously, we preliminarily reported that TC2N mediates the PI3K-Akt signaling pa...

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Bibliographic Details
Main Authors: Xiang-lin Hao, Yang-fan Lv, De-feng Li, Fu-hai Bai, Ji Gong, Guang-qiang Pan, Lin-xi Su, Ya-li Wang, Wan-lei Fu, Bo Liu, Lu Huang, Dong Yan, Qiu-lin Tan, Jin-yi Liu, Qiao-nan Guo
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Translational Medicine
Subjects:
TC2N
Breast cancer
Metastasis
Cancer stem cell
Fatty synthesis
PTEN neddylation
Online Access:https://doi.org/10.1186/s12967-023-04721-3

Internet

https://doi.org/10.1186/s12967-023-04721-3

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