Calcium Signaling Pathway Is Involved in the Shedding of ACE2 Catalytic Ectodomain: New Insights for Clinical and Therapeutic Applications of ACE2 for COVID-19

Calcium Signaling Pathway Is Involved in the Shedding of ACE2 Catalytic Ectodomain: New Insights for Clinical and Therapeutic Applications of ACE2 for COVID-19

The angiotensin-converting enzyme 2 (ACE2) is a type I integral membrane that exists in two forms: the first is a transmembrane protein; the second is a soluble catalytic ectodomain of ACE2. The catalytic ectodomain of ACE2 undergoes shedding by a disintegrin and metalloproteinase domain-containing...

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Bibliografiske detaljer
Main Authors: Artemio García-Escobar, Silvio Vera-Vera, Alfonso Jurado-Román, Santiago Jiménez-Valero, Guillermo Galeote, Raúl Moreno
Format: Article
Sprog:English
Udgivet: MDPI AG 2022-01-01
Serier:Biomolecules
Fag:
angiotensin-converting enzyme 2
calmodulin
COVID-19
soluble ACE2
ACE2 shedding
soluble catalytic ectodomain of ACE2
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