SUMO Modification of Hepatitis B Virus Core Mediates Nuclear Entry, Promyelocytic Leukemia Nuclear Body Association, and Efficient Formation of Covalently Closed Circular DNA

SUMO Modification of Hepatitis B Virus Core Mediates Nuclear Entry, Promyelocytic Leukemia Nuclear Body Association, and Efficient Formation of Covalently Closed Circular DNA

ABSTRACT Persistence of hepatitis B virus (HBV) infection is due to a nuclear covalently closed circular DNA (cccDNA), generated from the virion-borne relaxed circular DNA (rcDNA) genome in a process likely involving numerous cell factors from the host DNA damage response (DDR). The HBV core protein...

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Bibliographic Details
Main Authors: Samuel Hofmann, Verena Plank, Peter Groitl, Nathalie Skvorc, Katharina Hofmann, Julius Luther, Chunkyu Ko, Peter Zimmerman, Volker Bruss, Daniela Stadler, Arnaud Carpentier, Shahinda Rezk, Michael Nassal, Ulrike Protzer, Sabrina Schreiner
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:Microbiology Spectrum
Subjects:
HBV
chronic infection
HBV core protein
SUMO
PML-NBs
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00446-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.00446-23

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