Differentiation-inducing factor 1 activates cofilin through pyridoxal phosphatase and AMP-activated protein kinase, resulting in mitochondrial fission

Differentiation-inducing factor 1 activates cofilin through pyridoxal phosphatase and AMP-activated protein kinase, resulting in mitochondrial fission

Differentiation-inducing factor 1 (DIF-1) is a morphogen produced by Dictyostelium discoideum that inhibits the proliferation and migration of both D. discoideum and most mammalian cells. Herein, we assessed the effect of DIF-1 on mitochondria, because DIF-3, which is similar to DIF-1, reportedly lo...

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Bibliographic Details
Main Authors: Takeru Inoue, Koichi Miura, Ruzhe Han, Fumi Seto-Tetsuo, Masaki Arioka, Kazunobu Igawa, Katsuhiko Tomooka, Toshiyuki Sasaguri
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Journal of Pharmacological Sciences
Subjects:
Differentiation-inducing factor 1
Cofilin
AMP-Activated kinase
Pyridoxal phosphatase
Mitophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861323000117

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http://www.sciencedirect.com/science/article/pii/S1347861323000117

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