Sarcomeres Morphology and Z-Line Arrangement Disarray Induced by Ventricular Premature Contractions through the Rac2/Cofilin Pathway

Sarcomeres Morphology and Z-Line Arrangement Disarray Induced by Ventricular Premature Contractions through the Rac2/Cofilin Pathway

The most common ventricular premature contractions (VPCs) originate from the right ventricular outflow tract (RVOT), but the molecular mechanisms of altered cytoskeletons of VPC-induced cardiomyopathy remain unexplored. We created a RVOT bigeminy VPC pig model (<i>n</i> = 6 in each group...

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Bibliographic Details
Main Authors: Yu-Sheng Lin, Tzu-Hao Chang, Wan-Chun Ho, Shun-Fu Chang, Yung-Lung Chen, Shih-Tai Chang, Huang-Chung Chen, Kuo-Li Pan, Mien-Cheng Chen
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
actin cytoskeleton signaling
cardiomyopathy
Rac2/cofilin
sarcomere
ventricular premature contraction
Online Access:https://www.mdpi.com/1422-0067/22/20/11244

Internet

https://www.mdpi.com/1422-0067/22/20/11244

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