HIV-1 predisposed to acquiring resistance to maraviroc (MVC) and other CCR5 antagonists <it>in vitro </it>has an inherent, low-level ability to utilize MVC-bound CCR5 for entry

HIV-1 predisposed to acquiring resistance to maraviroc (MVC) and other CCR5 antagonists <it>in vitro </it>has an inherent, low-level ability to utilize MVC-bound CCR5 for entry

<p>Abstract</p> <p>Background</p> <p>Maraviroc (MVC) and other CCR5 antagonists are HIV-1 entry inhibitors that bind to- and alter the conformation of CCR5, such that CCR5 is no longer recognized by the viral gp120 envelope (Env) glycoproteins. Resistance to CCR5 antago...

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Bibliographic Details
Main Authors: Westby Mike, Jubb Becky, Salimiseyedabad Hamid, Ellett Anne, Jakobsen Martin R, Roche Michael, Lee Benhur, Lewin Sharon R, Churchill Melissa J, Gorry Paul R
Format: Article
Language:English
Published: BMC 2011-11-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/8/1/89

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http://www.retrovirology.com/content/8/1/89

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