Lack of STAT1 co-operative DNA binding protects against adverse cardiac remodelling in acute myocardial infarction

Lack of STAT1 co-operative DNA binding protects against adverse cardiac remodelling in acute myocardial infarction

In this study, we addressed the functional significance of co-operative DNA binding of the cytokine-driven transcription factor STAT1 (signal transducer and activator of transcription 1) in an experimental murine model of acute myocardial infarction (MI). STAT1 knock-in mice expressing a phenylalani...

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Bibliographic Details
Main Authors: Asmma Doudin, Theresa Riebeling, Julia Staab, Priyanka Rajeev Menon, Fred Lühder, Oliver Wirths, Uwe Vinkemeier, Aleksandar Ivetic, Thomas Meyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
STAT proteins
co-operative DNA binding
myocardial infarction
RNA sequencing
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.975012/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2023.975012/full

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