Genome sequencing unveils blaKPC-2-harboring plasmids as drivers of enhanced resistance and virulence in nosocomial Klebsiella pneumoniae

Genome sequencing unveils blaKPC-2-harboring plasmids as drivers of enhanced resistance and virulence in nosocomial Klebsiella pneumoniae

ABSTRACTThe threat posed by Klebsiella pneumoniae in healthcare settings has worsened due to the evolutionary advantages conferred by blaKPC-2-harboring plasmids (pKPC-2). However, the specific evolutionary pathway of nosocomial K. pneumoniae carrying pKPC-2 and its transmission between patients and...

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Bibliographic Details
Main Authors: Xinhong Han, Junxin Zhou, Lifei Yu, Lina Shao, Shiqi Cai, Huangdu Hu, Qiucheng Shi, Zhengan Wang, Xiaoting Hua, Yan Jiang, Yunsong Yu
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mSystems
Subjects:
carbapenem-resistant K. pneumoniae
KPC-2 carbapenemase
long-read sequencing
plasmid evolution
novel β-lactam/β-lactamase inhibitor combinations
Online Access:https://journals.asm.org/doi/10.1128/msystems.00924-23

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https://journals.asm.org/doi/10.1128/msystems.00924-23

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