Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape

Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape

Abstract Chimeric antigen receptor (CAR) T-cell therapy has demonstrated clinical response in treating both hematologic malignancies and solid tumors. Although instances of rapid tumor remissions have been observed in animal models and clinical trials, tumor relapses occur with multiple therapeutic...

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Bibliographic Details
Main Authors: You Zhai, Yicong Du, Guanzhang Li, Mingchen Yu, Huimin Hu, Changqing Pan, Di Wang, Zhongfang Shi, Xu Yan, Xuesong Li, Tao Jiang, Wei Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2023-12-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01708-w

Internet

https://doi.org/10.1038/s41392-023-01708-w

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