Accurate encoding and decoding by single cells: amplitude versus frequency modulation.

Cells sense external concentrations and, via biochemical signaling, respond by regulating the expression of target proteins. Both in signaling networks and gene regulation there are two main mechanisms by which the concentration can be encoded internally: amplitude modulation (AM), where the absolut...

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Bibliographic Details
Main Authors: Gabriele Micali, Gerardo Aquino, David M Richards, Robert G Endres
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-06-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4452646?pdf=render