Perturbation of Cortical Excitability in a Conditional Model of PCDH19 Disorder

Perturbation of Cortical Excitability in a Conditional Model of PCDH19 Disorder

PCDH19 epilepsy (DEE9) is an X-linked syndrome associated with cognitive and behavioral disturbances. Since heterozygous females are affected, while mutant males are spared, it is likely that DEE9 pathogenesis is related to disturbed cell-to-cell communication associated with mosaicism. However, the...

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Bibliographic Details
Main Authors: Didi Lamers, Silvia Landi, Roberta Mezzena, Laura Baroncelli, Vinoshene Pillai, Federica Cruciani, Sara Migliarini, Sara Mazzoleni, Massimo Pasqualetti, Maria Passafaro, Silvia Bassani, Gian Michele Ratto
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
PCDH19 epilepsy
girls clustering epilepsy
autism spectrum disorder
slow wave activity
excitation: inhibition ratio
NREM sleep
Online Access:https://www.mdpi.com/2073-4409/11/12/1939

Internet

https://www.mdpi.com/2073-4409/11/12/1939

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