Distribution and history of extensional stresses on vWF surrogate molecules in turbulent flow
Abstract The configuration of proteins is critical for their biochemical behavior. Mechanical stresses that act on them can affect their behavior leading to the development of decease. The von Willebrand factor (vWF) protein circulating with the blood loses its efficacy when it undergoes non-physiol...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-04034-9 |
| _version_ | 1798033433987907584 |
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| author | Oanh L. Pham Samuel E. Feher Quoc T. Nguyen Dimitrios V. Papavassiliou |
| author_facet | Oanh L. Pham Samuel E. Feher Quoc T. Nguyen Dimitrios V. Papavassiliou |
| author_sort | Oanh L. Pham |
| collection | DOAJ |
| description | Abstract The configuration of proteins is critical for their biochemical behavior. Mechanical stresses that act on them can affect their behavior leading to the development of decease. The von Willebrand factor (vWF) protein circulating with the blood loses its efficacy when it undergoes non-physiological hemodynamic stresses. While often overlooked, extensional stresses can affect the structure of vWF at much lower stress levels than shear stresses. The statistical distribution of extensional stress as it applies on models of the vWF molecule within turbulent flow was examined here. The stress on the molecules of the protein was calculated with computations that utilized a Lagrangian approach for the determination of the molecule trajectories in the flow filed. The history of the stresses on the proteins was also calculated. Two different flow fields were considered as models of typical flows in cardiovascular mechanical devises, one was a Poiseuille flow and the other was a Poiseuille–Couette flow field. The data showed that the distribution of stresses is important for the design of blood flow devices because the average stress can be below the critical value for protein damage, but tails of the distribution can be outside the critical stress regime. |
| first_indexed | 2024-04-11T20:30:25Z |
| format | Article |
| id | doaj.art-6ea0b6f4298c446b94d3b41d3d800257 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T20:30:25Z |
| publishDate | 2022-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6ea0b6f4298c446b94d3b41d3d8002572022-12-22T04:04:31ZengNature PortfolioScientific Reports2045-23222022-01-0112111410.1038/s41598-021-04034-9Distribution and history of extensional stresses on vWF surrogate molecules in turbulent flowOanh L. Pham0Samuel E. Feher1Quoc T. Nguyen2Dimitrios V. Papavassiliou3School of Chemical, Biological and Materials Engineering, The University of OklahomaSchool of Chemical, Biological and Materials Engineering, The University of OklahomaSchool of Chemical, Biological and Materials Engineering, The University of OklahomaSchool of Chemical, Biological and Materials Engineering, The University of OklahomaAbstract The configuration of proteins is critical for their biochemical behavior. Mechanical stresses that act on them can affect their behavior leading to the development of decease. The von Willebrand factor (vWF) protein circulating with the blood loses its efficacy when it undergoes non-physiological hemodynamic stresses. While often overlooked, extensional stresses can affect the structure of vWF at much lower stress levels than shear stresses. The statistical distribution of extensional stress as it applies on models of the vWF molecule within turbulent flow was examined here. The stress on the molecules of the protein was calculated with computations that utilized a Lagrangian approach for the determination of the molecule trajectories in the flow filed. The history of the stresses on the proteins was also calculated. Two different flow fields were considered as models of typical flows in cardiovascular mechanical devises, one was a Poiseuille flow and the other was a Poiseuille–Couette flow field. The data showed that the distribution of stresses is important for the design of blood flow devices because the average stress can be below the critical value for protein damage, but tails of the distribution can be outside the critical stress regime.https://doi.org/10.1038/s41598-021-04034-9 |
| spellingShingle | Oanh L. Pham Samuel E. Feher Quoc T. Nguyen Dimitrios V. Papavassiliou Distribution and history of extensional stresses on vWF surrogate molecules in turbulent flow Scientific Reports |
| title | Distribution and history of extensional stresses on vWF surrogate molecules in turbulent flow |
| title_full | Distribution and history of extensional stresses on vWF surrogate molecules in turbulent flow |
| title_fullStr | Distribution and history of extensional stresses on vWF surrogate molecules in turbulent flow |
| title_full_unstemmed | Distribution and history of extensional stresses on vWF surrogate molecules in turbulent flow |
| title_short | Distribution and history of extensional stresses on vWF surrogate molecules in turbulent flow |
| title_sort | distribution and history of extensional stresses on vwf surrogate molecules in turbulent flow |
| url | https://doi.org/10.1038/s41598-021-04034-9 |
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