Interleukin-10 haplotypes are not associated with acute cerebral ischemia or high-risk transcranial Doppler in a newborn cohort of 395 children with sickle cell anemia
ABSTRACT Background: The etiology of stroke, a severe complication of sickle cell anemia, involves inflammatory processes. However, the pathogenetic mechanisms are unknown. The aim of this study was to evaluate the influence of interleukin-10 polymorphisms and haplotypes on the risk of acute cerebr...
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| Format: | Article |
| Language: | English |
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Elsevier
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| Series: | Revista Brasileira de Hematologia e Hemoterapia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842017000200108&lng=en&tlng=en |
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| author | André Rolim Belisário Rahyssa Rodrigues Sales Nayara Evelin Toledo Cibele Velloso-Rodrigues Célia Maria Silva Marcos Borato Viana |
| author_facet | André Rolim Belisário Rahyssa Rodrigues Sales Nayara Evelin Toledo Cibele Velloso-Rodrigues Célia Maria Silva Marcos Borato Viana |
| author_sort | André Rolim Belisário |
| collection | DOAJ |
| description | ABSTRACT Background: The etiology of stroke, a severe complication of sickle cell anemia, involves inflammatory processes. However, the pathogenetic mechanisms are unknown. The aim of this study was to evaluate the influence of interleukin-10 polymorphisms and haplotypes on the risk of acute cerebral ischemia and high-risk transcranial Doppler in 395 children with sickle cell anemia from the state of Minas Gerais, Brazil. Methods: Interleukin-10 haplotypes were determined by polymerase chain reaction-restriction fragment length polymorphism and sequencing. The outcomes studied were acute cerebral ischemia and high-risk transcranial Doppler. Clinical data were retrieved from the children's records. Results: There was no statistically significant difference in the frequencies of polymorphisms and haplotypes between children with and without acute cerebral ischemia or children with or without high-risk transcranial Doppler. These data are consistent with a previous report that showed an absence of association between interleukin-10 plasma levels and high-risk transcranial Doppler velocity in children with sickle cell anemia. Conclusion: Interleukin-10 haplotypes were not associated with the risk of acute cerebral ischemia or high-risk transcranial Doppler velocity in children with sickle cell anemia from the state of Minas Gerais, Brazil. |
| first_indexed | 2024-12-20T02:44:40Z |
| format | Article |
| id | doaj.art-6ea0f4d0e64043deafecb43b6d8712ce |
| institution | Directory Open Access Journal |
| issn | 1806-0870 |
| language | English |
| last_indexed | 2024-12-20T02:44:40Z |
| publisher | Elsevier |
| record_format | Article |
| series | Revista Brasileira de Hematologia e Hemoterapia |
| spelling | doaj.art-6ea0f4d0e64043deafecb43b6d8712ce2022-12-21T19:56:12ZengElsevierRevista Brasileira de Hematologia e Hemoterapia1806-087039210811410.1016/j.bjhh.2016.09.017S1516-84842017000200108Interleukin-10 haplotypes are not associated with acute cerebral ischemia or high-risk transcranial Doppler in a newborn cohort of 395 children with sickle cell anemiaAndré Rolim BelisárioRahyssa Rodrigues SalesNayara Evelin ToledoCibele Velloso-RodriguesCélia Maria SilvaMarcos Borato VianaABSTRACT Background: The etiology of stroke, a severe complication of sickle cell anemia, involves inflammatory processes. However, the pathogenetic mechanisms are unknown. The aim of this study was to evaluate the influence of interleukin-10 polymorphisms and haplotypes on the risk of acute cerebral ischemia and high-risk transcranial Doppler in 395 children with sickle cell anemia from the state of Minas Gerais, Brazil. Methods: Interleukin-10 haplotypes were determined by polymerase chain reaction-restriction fragment length polymorphism and sequencing. The outcomes studied were acute cerebral ischemia and high-risk transcranial Doppler. Clinical data were retrieved from the children's records. Results: There was no statistically significant difference in the frequencies of polymorphisms and haplotypes between children with and without acute cerebral ischemia or children with or without high-risk transcranial Doppler. These data are consistent with a previous report that showed an absence of association between interleukin-10 plasma levels and high-risk transcranial Doppler velocity in children with sickle cell anemia. Conclusion: Interleukin-10 haplotypes were not associated with the risk of acute cerebral ischemia or high-risk transcranial Doppler velocity in children with sickle cell anemia from the state of Minas Gerais, Brazil.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842017000200108&lng=en&tlng=enSickle cell anemiaStrokePolymorphismInterleukin-10Transcranial Doppler ultrasound |
| spellingShingle | André Rolim Belisário Rahyssa Rodrigues Sales Nayara Evelin Toledo Cibele Velloso-Rodrigues Célia Maria Silva Marcos Borato Viana Interleukin-10 haplotypes are not associated with acute cerebral ischemia or high-risk transcranial Doppler in a newborn cohort of 395 children with sickle cell anemia Revista Brasileira de Hematologia e Hemoterapia Sickle cell anemia Stroke Polymorphism Interleukin-10 Transcranial Doppler ultrasound |
| title | Interleukin-10 haplotypes are not associated with acute cerebral ischemia or high-risk transcranial Doppler in a newborn cohort of 395 children with sickle cell anemia |
| title_full | Interleukin-10 haplotypes are not associated with acute cerebral ischemia or high-risk transcranial Doppler in a newborn cohort of 395 children with sickle cell anemia |
| title_fullStr | Interleukin-10 haplotypes are not associated with acute cerebral ischemia or high-risk transcranial Doppler in a newborn cohort of 395 children with sickle cell anemia |
| title_full_unstemmed | Interleukin-10 haplotypes are not associated with acute cerebral ischemia or high-risk transcranial Doppler in a newborn cohort of 395 children with sickle cell anemia |
| title_short | Interleukin-10 haplotypes are not associated with acute cerebral ischemia or high-risk transcranial Doppler in a newborn cohort of 395 children with sickle cell anemia |
| title_sort | interleukin 10 haplotypes are not associated with acute cerebral ischemia or high risk transcranial doppler in a newborn cohort of 395 children with sickle cell anemia |
| topic | Sickle cell anemia Stroke Polymorphism Interleukin-10 Transcranial Doppler ultrasound |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842017000200108&lng=en&tlng=en |
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