Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development

Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development

Early mouse development is accompanied by dynamic changes in chromatin modifications, including G9a-mediated histone H3 lysine 9 dimethylation (H3K9me2), which is essential for embryonic development. Here we show that genome-wide accumulation of H3K9me2 is crucial for postimplantation development, a...

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Bibliographic Details
Main Authors: Jan J Zylicz, Sabine Dietmann, Ufuk Günesdogan, Jamie A Hackett, Delphine Cougot, Caroline Lee, M Azim Surani
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-11-01
Series:eLife
Subjects:
epigenetic
stem cell
epiblast
post-implantation
primed pluripotency
histone
Online Access:https://elifesciences.org/articles/09571

Internet

https://elifesciences.org/articles/09571

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