Immune hyporeactivity to bacteria and multiple TLR-ligands, yet no response to checkpoint inhibition in patients just after meeting Sepsis-3 criteria.

Immune hyporeactivity to bacteria and multiple TLR-ligands, yet no response to checkpoint inhibition in patients just after meeting Sepsis-3 criteria.

<h4>Rationale</h4>The immune profile of sepsis patients is incompletely understood and hyperinflammation and hypoinflammation may occur concurrently or sequentially. Immune checkpoint inhibition (ICI) may counter hypoinflammation but effects are uncertain. We tested the reactivity of sep...

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Bibliographic Details
Main Authors: Alexandra Bick, Willem Buys, Andrea Engler, Rabea Madel, Mazen Atia, Francesca Faro, Astrid M Westendorf, Andreas Limmer, Jan Buer, Frank Herbstreit, Carsten J Kirschning, Jürgen Peters
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0273247

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https://doi.org/10.1371/journal.pone.0273247

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